刘郁涛

教育经历

2015/9－2019/12，南开大学，微生物学，博士

2013/9－2015/6，哈尔滨工业大学，微生物学，硕士

2007/9－20011/6，天津医科大学，生物医学工程本科

工作经历

2023/10－至今，南开大学，泰达生物技术研究院，副研究员

2020/5－2023/10，南开大学，泰达生物技术研究院，博士后，助理研究员

基本信息

    近年来一直从事肠道致病菌致病相关研究，主要就方向包括：（1）肠道致病微生物的致病机制；（2）肠道致病微生物与肠道菌群的互作机制；（3）治疗肠道疾病的工程益生菌的开发。期待与具有临床医学、药学、信息科学、材料科学、微生物学等研究背景的老师同学展开合作。

    近五年，相关研究成果发表于PNAS（2022）, Nature Communications（2021，2023），Gut Microbes（2022, 2022, 2024），mBio（2020），Communications Biology（2022），Journal Of Infectious Diseases（2024）等发表SCI论文18篇。

联系方式：

Email：liuyutao623@nankai.edu.cn

近期代表性论文： (*corresponding author, #co-first author, IF, impact factor)

(1) Liu X^#, Liu Y^#, Zhao X, Li X, Yao T, Liu R, Wang Q, Wang Q, Li D, Chen X, Liu B^*, Feng L^*. Salmonella enterica serovar Typhimurium remodels mitochondrial dynamics of macrophages via the T3SS effector SipA to promote intracellular proliferation. Gut Microbes. 2024 Jan-Dec;16(1):2316932.(IF=12.2)

(2) Li X^#, Jiang L^#, Zhang S^#, Zhou J, Liu L, Jin C, Sun H, Wang Q, Liu Y^*, Pang Y^*. Uropathogenic Escherichia coli subverts host autophagic defenses by stalling pre-autophagosomal structures to escape lysosome exocytosis. J Infect Dis. 2024 Feb 8:jiae063. (IF=6.4)

(3) Liu B^#, Jiang L^#, Liu Y^#, Sun H, Yan J, Kang C, Yang B^*. Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization. Nat Commun. 2023 Nov 9;14(1):7227. (IF=16.6)

(4) Wu P^#, Wang Q^#, Yang Q, Feng X, Liu X, Sun H, Yan J, Kang C, Liu B, Liu Y^*, Yang B^*. A Novel Role of the Two-Component System Response Regulator UvrY in Enterohemorrhagic Escherichia coli O157:H7 Pathogenicity Regulation. Int J Mol Sci.2023 Jan 24;24(3):2297. (IF=5.6)

(5) Liu B^#, Liu Y^#, Yang B, Wang Q, Liu X, Qin J, Zhao K, Li F, Feng X, Li L, Wu P, Liu M, Zhu S, Feng L, Wang L^*. Escherichia coli O157:H7 senses microbiota-produced riboflavin to increase its virulence in the gut. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2212436119. (IF=11.1)

(6) Wu J^#, Liu Y^#, Li W, Li F, Liu R, Sun H, Qin J, Feng X, Huang D^*, Liu B^*. MlrA, a MerR family regulator in Vibrio cholerae, senses the anaerobic signal in the small intestine of the host to promote bacterial intestinal colonization. Gut Microbes.2022 Jan-Dec;14(1):2143216. (IF=12.2)

(7) Sun H^#, Wang M^#, Liu Y^#, Wu P, Yao T, Yang W, Yang Q, Yan J, Yang B^*. Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7. Gut Microbes.2022 Jan-Dec;14(1):2110822. (IF=12.2)

(8) Liu Y^#, Xu T^#, Wang Q, Huang J, Zhu Y, Liu X, Liu R, Yang B^*, Zhou K^*. Vibrio cholerae senses human enteric α-defensin 5 through a CarSR two-component system to promote bacterial pathogenicity.Commun Biol.2022 Jun 8;5(1):559. (IF=5.9)

(9) Liu Y^#, Liu B^#, Xu T, Wang Q, Li W, Wu J, Zheng X, Liu B, Liu R, Liu X, Guo X, Feng L^*, Wang L. A fructose/H⁺ symporter controlled by a LacI-type regulator promotes survival of pandemic Vibrio cholerae in seawater.Nat Commun. 2021 Jul 30;12(1):4649. (IF=16.6)

(10) Liu Y^#, Han R^#, Wang J, Yang P, Wang F, Yang B^*. Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7. mBio.2020 Nov 10;11(6):e02470-20. (IF=6.4)