蒋玲艳

蒋玲艳，副研究员，硕士生导师，传染病溯源预警与智能决策全国重点实验室PI。2006年毕业于西北大学生命科学与技术基地班，获学士学位；2014年毕业于南开大学生物化学与分子生物学专业，获博士学位。2015年进入南开大学生态学博士后流动站从事博士后研究，2017年留校任教，现任南开大学泰达生物技术研究院副研究员。

长期致力于病原菌致病机理及其与宿主细胞互作机制的研究，以第一或通讯作者在 Nature Communications、PLoS Pathogens、Gut Microbes国际权威期刊发表SCI论文40余篇。作为项目负责人，主持省部级以上科研项目6项，其中包括3项国家自然科学基金、1项天津市科技重大专项与工程项目，1项天津市自然科学基金项目及1项中国博士后科学基金。作为课题骨干，参与2项国家重点研发计划项目及1项国家自然科学基金重点项目。

部分代表性论文：

Lingyan Jiang, Peisheng Wang, Xiaorui Song, Huan Zhang, Shuangshuang Ma, Jingting Wang, Wanwu Li, Runxia Lv, Xiaoqian Liu, Shuai Ma, Jiaqi Yan, Haiyan Zhou, Di Huang, Zhihui Cheng, Chen Yang, Lu Feng^*, Lei Wang^*. Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence. Nature Communications, 2021, 12(1):879. 

Bin Liu^#, Lingyan Jiang^#(Co-first), Yutao Liu^#, Hongmin Sun, Jun Yan, Chenbo Kang, Bin Yang^*. Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization. Nature Communications. 2023, 14(1):7227.

Shuai Ma^#, Bin Yang^#, Yuyang Sun, Xinyue Wang, Houliang Guo, Ruiying Liu, Ting Ye, Chenbo Kang, Jingnan Chen,  Lingyan Jiang^*. Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages. Elife. 2025, 13:RP103714.

Hongmin Sun^#, Lingyan Jiang^#(Co-first), Jingnan Chen, Chenbo Kang, Jun Yan, Shuai Ma, Mengjie Zhao, Houliang Guo, Bin Yang*. Genomic island-encoded LmiA regulates acid resistance and biofilm formation in enterohemorrhagic Escherichia coli O157:H7. Gut Microbes. 2025,17(1):2443107.

Xinyue Wang, Yuyang Sun, Houliang Guo, Xiaolin Yan, Shuai Ma, Bin Yang*, Lingyan Jiang*. Xylose utilization promotes Salmonella replication within macrophages and systemic infection in mice. Virulence. 2024 Dec;15(1):2435381.

Shuai Ma, Wanwu Li, Xinyue Wang, Yuyang Sun, Houliang Guo, Jiaqi Ma, Lingyan Jiang*. The putative AraC-type transcriptional regulator STM1082 facilitates Salmonella pathogenicity through modulation of intestinal Invasion and intracellular replication. Virulence. 2025, 16(1):2554297.

Xueping Li^#, Lingyan Jiang^#(Co-first), Si Zhang^#, Jiarui Zhou, Le Liu, Chen Jin, Hongmin Sun, Qian Wang, Yutao Liu^*, Yu Pang^*. Uropathogenic Escherichia coli subverts host autophagic defenses by stalling pre-autophagosomal structures to escape lysosome exocytosis. Journal Of Infectious Diseases. 2024 Feb 8:jiae063.

Xinyue Wang^#, Bin Yang^#, Shuangshuang Ma^#, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang^*. Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization. Microbiology Spectrum. 2023, 11(6):e0225323. doi: 10.1128/spectrum.02253-23.

Lingyan Jiang, Wanwu Li, Xi Hou, Shuai Ma, Xinyue Wang, Xiaolin Yan, Bin Yang, Di Huang, Bin Liu, Lu Feng^*. Nitric oxide is a host cue for Salmonella Typhimurium systemic infection in mice. Communications Biology. 2023, 6(1):501.

Lingyan Jiang, Wen Yang, Xinlei Jiang, Ting Yao, Lu Wang, Bin Yang^*. Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7. Gut Microbes. 2021;13(1):1992237. doi: 10.1080/19490976.2021.1992237.

Wanwu Li^#, Lingyan Jiang^#(Co-first), Xiaoqian Liu, Rui Guo, Shuai Ma, Jingting Wang, Shuangshuang Ma, Shujie Li, Huiying Li^*. YhjC is a novel transcriptional regulator required for Shigella flexneri virulence. Virulence. 2021, 12(1): 1661–1671.

Shuangshuang Ma^#, Lingyan Jiang^#(Co-first), Jingting Wang, Xiaoqian Liu, Wanwu Li, Shuai Ma, Lu Feng^*. Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity of Salmonella typhimurium. Virulence. 2021, 12(1):298–311.

Zhiqiu Yin^#, Si Zhang^#, Yi Wei^#, Meng Wang, Shuangshuang Ma, Shuang Yang, Jingting Wang, Chao Yuan^*, Lingyan Jiang^*, Yuhui Du^*. Horizontal gene transfer clarifies taxonomic confusion and promotes the genetic diversity and pathogenicity of Plesiomonas shigelloides. mSystems. 2020, 5:e00448–20.

Lingyan Jiang, Peisheng Wang, Xiaomin Li, Runxia Lv, Lin Wang, Bin Yang, Di Huang, Lu Feng^*, Bin Liu^*. PagR mediates the precise regulation of Salmonella pathogenicity island 2 gene expression in response to magnesium and phosphate signals in Salmonella Typhimurium. Cellular Microbiology. 2019, 22(2):e13125.

Lingyan Jiang, Lu Feng, Bin Yang, Wenwen Zhang, Peisheng Wang, Xiaohan Jiang, Lei Wang^*. Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion. PLoS Pathogens. 2017, 13(6):e1006429.