杨斌

    杨斌， 2008年毕业于兰州大学生物科学基地班，获学士学位；2015年毕业于南开大学微生物专业，获博士学位。2015年起进入南开大学工作，现任泰达生物技术研究院副研究员，博士生导师。主要研究方向为：肠道致病菌致病机制和感染位点识别机制。在Nature Communications, Cell Reports, FEMS Microbiology Reviews, Gut Microbes, mBio等微生物学期刊上共发表40余篇SCI论文。主持各类科研项目7项，包括国家自然科学基金项目2项；天津市自然科学基金3项；中央高校基本科研业务费2项。入选天津市“131”创新型人才，南开大学百名青年学科带头人（百青）。

Email：yangbin@nankai.edu.cn

部分代表性论文：

1. Sun H(#), Jiang L(#), Chen J, Kang C, Yan J, Ma S, Zhao M, Guo H, Yang B*. Genomic island-encoded LmiA regulates acid resistance and biofilm formation in enterohemorrhagic Escherichia coli O157:H7. Gut Microbe 2025, 17(1):2443107. 

2. Sun H(#), Huang D(#), Pang Y(#), Chen J(#), Kang C(#), Zhao M, Yang B*. Key roles of two-component systems in intestinal signal sensing and virulence regulation in enterohemorrhagic Escherichia coli. FEMS Microbiology Reviews 2024, 48(6):fuae028.

3. Yao T(#), Liu X(#), Li D(#), Huang Y, Yang W, Liu R, Wang Q, Li X, Zhou J, Jin C, Liu Y, Yang B*, Pang Y*. Two-component system RstAB promotes the pathogenicity of adherent-invasive Escherichia coli in response to acidic conditions within macrophages. Gut Microbes 2024, 16(1):2356642.

4. Wang F(#), Sun H(#), Kang C, Yan J, Chen J, Feng X*, Yang B*. Genomic island-encoded regulatory proteins in enterohemorrhagic Escherichia coli O157:H7. Virulence 2024, 15(1):2313407.

5. Wang X, Sun Y, Guo H, Yan X, Ma S, Yang B*, Jiang L*. Xylose utilization promotes Salmonella replication within macrophages and systemic infection in mice. Virulence 2024, 15(1):2435381. doi:10.1080/21505594.2024.2435381.

6. Liu B(#), Jiang L(#), Liu Y(#), Sun H, Yan J, Kang C, Yang B*. Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization. Nature Communications 2023, 14(1): 7227.

7. Yang W(#), Sun H(#), Yan J, Kang C, Wu, J, Yang B*. Enterohemorrhagic Escherichia coli senses microbiota-derived nicotinamide to increase its virulence and colonization in the large intestine. Cell Reports 2023, 42(6):112638.

8. Wu P (#), Wang Q(#), Yang Q, Feng X, Liu X, Sun H, Yan J, Kang C, Liu B, Liu Y*, Yang B*. A novel role of the two-component system response regulator UvrY in enterohemorrhagic Escherichia coli O157:H7 pathogenicity regulation. International Journal of Molecular Sciences 2023, 24(3):2297.

9. Sun H(#), Wang M(#), Liu Y(#), Wu P, Yao T, Yang W, Yang Q, Yan J, Yang B*. Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7. Gut Microbes 2022, 14(1):2110822.

10. Feng L(#), Yang B(#), Xu Y, Xiong Y, Wang F, Liu B, Yang W, Yao T, Wang L*. Elucidation of a complete mechanical signaling and virulence activation pathway in enterohemorrhagic Escherichia coli. Cell Reports 2022, 39: 110614.

11. Wang F(#), Yao T(#), Yang W(#), Wu P, Liu Y, Yang B*. Protocol to detect nucleotide-protein interaction in vitro using a non-radioactive competitive electrophoretic mobility shift assay. STAR Protocols 2022, 3(4):101730.

12. Liu Y(#), Xu T(#), Wang Q, Huang J, Zhu Y, Liu X, Liu R, Yang B*, Zhou K*. Vibrio cholerae senses human enteric alpha-defensin 5 through a CarSR two-component system to promote bacterial pathogenicity. Communications Biology 2022, 5(1):559.

13. Fan Y, Bai J, Xi D, Yang B*. RpoE facilitates stress-resistance, invasion, and pathogenicity of Escherichia coli K1. Microorganisms 2022, 10(5):879.

14. Jiang L(#), Yang W(#), Jiang X(#), Yao T, Wang Lu, Yang B*. Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7. Gut Microbes 2021, 13(1): e1992237.

15. Liu Y(#), Han R(#), Wang J, Yang P, Wang F, Yang B*. Magnesium sensing regulates intestinal colonization of enterohemorrhagic Escherichia coli O157:H7. mBio 2020, 11(6): e02470-20. (Cover Article)

16. Liu B(#), Wang J(#), Wang L, Ding P, Yang P, Yang B*. Transcriptional activator OvrA encoded in O Island 19 modulates virulence gene expression in Enterohemorrhagic Escherichia coli O157:H7. Journal of Infectious Diseases 2020, 221:820-9. (Cover Article)

17. Liu Y(#), Liu B(#), Yang P, Wang T, Chang Z, Wang J, Wang Q, Li W, Wu J, Huang D, Jiang L, Yang B*. LysR-type transcriptional regulator OvrB encoded in O island 9 drives enterohemorrhagic Escherichia coli O157:H7 virulence. Virulence 2019, 10:783-92.

18. Liu Y(#), Li S(#), Li W, Wang P, Ding P, Li L, Wang J, Yang P, Wang Q, Xu T, Xiong Y, Yang B*. RstA, a two-component response regulator, plays important roles in multiple virulence-associated processes in enterohemorrhagic Escherichia coli O157:H7. Gut pathogens 2019, 11:53.

19. Yang B, Jiang L, Huang D, Ding P, Liu B, Wang L*. Molecular mechanisms of infection site recognition by enteric pathogens. Sci Sin Vitae, 2019, 49:1069-75.

20. Yang F, Yang L, Chang Z, Chang L, Yang B*. Regulation of virulence and motility by acetate in enteropathogenic Escherichia coli. International Journal of Medical Microbiology 2018, 308:840-7.

21. Yang B, Wang S, Huang J, Yin Z, Jiang L, Hou W, Li X, Feng L*.Transcriptional activator GmrA, encoded in genomic island OI-29, controls the motility of Enterohemorrhagic Escherichia coli O157:H7. Frontiers in Microbiology 2018, 9:338.

22. Yang B, Jiang L, Wang S, Wang L*. Global transcriptional regulation by BirA in enterohemorrhagic Escherichia coli O157:H7. Future Microbiology 2018, 13:757-769.

23. Yang B, Senchenkova SN, Naumenko OI, Shashkov AS, Liu B, Perepelov AV, Knirel YA *. Structural and genetic relatedness of the O-antigens of Escherichia coli O50 and O2. Carbohydrate Research 2018, 464:8-11.

24. Wang S, Yang F, Yang B*. Global effect of CsrA on gene expression in enterohemorrhagic Escherichia coli O157:H7. Research in Microbiology 2017, 168:700-9.

25. Yang B(#), Feng L(#), Wang F, Wang L*. Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection. Nature Communications 2015, 6:6592.