黄笛

发布者:禇佳强发布时间:2016-04-21浏览次数:330

黄笛
学历: 博士
职称:讲师
专业方向: 微生物遗传
招生专业: 微生物学,生化与分子生物学
人员简介:

    

    黄笛,南开大学泰达生物技术研究院讲师;2008年毕业于大连理工大学,获学士学位,2010年获天津大学硕士学位,2013年获天津大学博士学位,导师闻建平教授。2013年7月进入南开大学工作,目前主要利用合成生物学和系统生物学方法从事微生物寡糖、糖蛋白等产物的系统性研究,在功能寡糖化合物的微生物制造、重要致病菌糖蛋白结合疫苗的微生物细胞工厂构建以及微生物合成体系的组学系统研究等方向取得了重要成果。任现职以来以第一或通讯作者在Metabolic Engineering(一区)、Bioresource Technology(一区)、Microbial Cell Factories(二区)、Applied Microbiology and Biotechnology(二区)、Journal of Industrial Microbiology and Biotechnology(二区)等生物期刊上发表10.5篇SCI论文(一区3篇、二区7篇、四区0.5篇)。目前,主持1项国家自然科学基金项目,1项天津市自然科学基金项目,2项中央高校基本科研业务费,作为学术课题骨干参与完成了3项973项目、2项国家自然科学基金重点(国际合作)项目。2016年入选天津市“131”第三层次人才。

  

    Emailhuangdi@nankai.edu.cn


部分发表论文列表

  1. Di Huang, Kexin Yang, Jia Liu, Yingying Xu, Yuanyuan Wang, Ru Wang, Bin Liu*, Lu Feng*, Metabolic engineering of Escherichia coli for the production of 2′-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. Metabolic Engineering, 2017, 41:23-38. (IF: 7.808)

  2. Di Huang*, Ru Wang, Wenjie Du, Guanyi Wang, Menglei Xia, Activation of glycerol metabolic pathway by evolutionary engineering of Rhizopus oryzae to strengthen the fumaric acid biosynthesis from crude glycerol. Bioresource Technology, 2015, 196:263-272. (IF: 6.669)

  3. Di Huang, Jia Liu, Yanfei Qi, Kexin Yang, Yingying Xu, Lu Feng*, Synergistic hydrolysis of xylan using novel xylanases, β-xylosidases, and an α-L-arabinofuranosidase from Geobacillus thermodenitrificans NG80-2. Applied Microbiology and Biotechnology, 2017, 101(15):6023-6037. (IF: 3.670)

  4. Di Huang#, Yongpeng Yao#, Hang Zhang, Zhu Mei, Ru Wang, Lu Feng, Bin Liu*, Directed optimization of a newly identified squalene synthase from Mortierella alpine based on sequence truncation and site-directed mutagenesis. Journal of Industrial Microbiology and Biotechnology, 2015, 42(10):1341-1352. (#co-first author) (IF: 2.993)

  5. Huanhuan Liu#, Di Huang#, Lina Jin#, Cheng Wang, Shaoxiong Liang, Jianping Wen*, Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction. Microbial Cell Factories, 2017, 16:120. (#co-first author) (IF: 4.402)

  6. Huanhuan Liu#, Di Huang#, Jianping Wen*, Integrated intracellular metabolic profiling and pathway analysis approaches reveal complex metabolic regulation by Clostridium acetobutylicum. Microbial Cell Factories, 2016, 15:36. (#co-first author) (IF: 4.402)

  7. Guanyi Wang#, Di Huang#, Yong Li, Jianping Wen*, Xiaoqiang Jia, A metabolic-based approach to improve xylose utilization for fumaric acid production from acid pretreated wheat bran by Rhizopus oryzae. Bioresource Technology, 2015, 180:119-127. (#co-first author) (IF: 6.669)

  8. Wenjie Du#, Di Huang#*, Menglei Xia, Jianping Wen*, Ming Huang, Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. Journal of Industrial Microbiology and Biotechnology, 2014, 41(7):1131-1143. (#co-first author) (IF: 2.993)

  9. Jun Wang#, Huanhuan Liu#, Di Huang#, Lina Jin, Cheng Wang, Jianping Wen*, Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. Applied Microbiology and Biotechnology, 2017, 101(6):2447-2465. (#co-first author) (IF: 3.670)

  10. Cheng Wang*#, Di Huang#, Shaoxiong Liang. Identification and metabolomic analysis of chemical elicitors for tacrolimus accumulation in Streptomyces tsukubaensis. Applied Microbiology and Biotechnology, 2018, 102:7541-7553. (#co-first author) (IF: 3.670)

  11. Yuhui Du, Huiying Li, Zhiqiu Yin, Antoni Rozalski, Agnieszka Torzewska, Pan Yang, Chengqian Qian, Tingting Xu, Hengchun Cao, Pan Wu, Lingyan Jiang, Xi Guo, Di Huang, Bin Liu*. Development of a molecular serotyping scheme and a multiplexed luminex-based array for Providencia. Journal of Microbiological Methods, 2018, 153:14-23. (*co-correspondence author) (IF: 1.803)

  12. Di Huang, Shanshan Li, Menglei Xia, Jianping Wen*, Xiaoqiang Jia. Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. Microbial Cell Factories, 2013, 12:52. (IF: 4.402)

  13. Di Huang, Menglei Xia, Shanshan Li, Jianping Wen*, Xiaoqiang Jia. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. Journal of Industrial Microbiology and Biotechnology, 2013, 40(9):1023-1037. (IF: 2.993)

  14. Di Huang, Jianping Wen*, Guoying Wang, Guanghai Yu, Xiaoqiang Jia and Yunlin Chen. In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement. Applied Microbiology and Biotechnology, 2012, 94(3):637-649. (IF: 3.670)

  15. Di Huang, Xiaoqiang Jia, Jianping Wen*, Guoying Wang, Guanghai Yu, Qinggele Caiyin and Yunlin Chen. Metabolic flux analysis and principal nodes identification for daptomycin production improvement by Streptomyces roseosporus. Applied Biochemistry and Biotechnology, 2011, 165(7-8):1725-1739. (IF: 2.140)

  16. Shanshan Li, Di Huang, Yong Li, Jianping Wen*, Xiaoqiang Jia. Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis. Microbial Cell Factories, 2012, 11:101. (IF: 4.402)

  17. Guanyi Wang#, Di Huang#, Haishan Qi, Jianping Wen*, Xiaoqiang Jia. Rational medium optimization based on comparative metabolic profiling analysis to improve fumaric acid production. Bioresource Technology, 2013, 137:1-8. (#co-first author) (IF: 6.669)

  18. Menglei Xia#, Di Huang#, Shanshan Li, Jianping Wen*, Xiaoqiang Jia, Yunlin Chen. Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. Biotechnology and Bioengineering, 2013, 110(10):2717-2730. (#co-first author) (IF: 4.260)

  19. Sumin Zhao, Di Huang, Haishan Qi, Jianping Wen*, Xiaoqiang Jia. Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus. Applied Microbiology and Biotechnology, 2013, 97(12):5329-5341. (IF: 3.670)

  20. Shouzhi Yu, Di Huang, Jianping Wen*, Shuang Li, Yunlin Chen, Xiaoqiang Jia. Metabolic profiling of a Rhizopus oryzae fumaric acid production mutant generated by femtosecond laser irradiation. Bioresource Technology, 2012, 114:610-615. (IF: 6.669)