刘斌

刘斌，南开大学传染病溯源预警与智能决策全国重点实验室副主任，泰达生物技术研究院副院长，“分子微生物学与技术”教育部重点实验室主任、“微生物功能基因组与检测技术”教育部工程研究中心主任。

     长期进行致病菌进化机制和致病性机理的研究，在该领域具有丰富经验。作为通讯/第一作者，已累计在Nature Microbiology，Nature Communications，PNAS，Science Signaling，Gut Microbes，FEMS Microbiology Reviews, Nucleic Acids Research，mBio， Metabolic Engineering等期刊发表70篇论文。获2018年法国梅里埃研究院青年科学家奖。担任法国国家科研署(French National Research Agency)项目评审专家。

申请人作为通讯/第一作者发表的部分论文的列表：

 (*corresponding author, #co-first author, IF, impact factor)

1. Yutao Liu, Jialin Wu, Ruiying Liu, Fan Li, Leyan Xuan, Qian Wang, Dan Li, XinTong Chen, Hao Sun, Xiaoya Li, Chen Jin, Di Huang, Linxing Li, Guosheng Tang*, Bin Liu*. Vibrio cholerae virulence is blocked by chitosan oligosaccharide-mediated inhibition of ChsR activity. Nature Microbiology. 2024. 9:2909-2922. (IF: 20.5)

2. Linxing Li, Yutao Liu, Dan Liu, Jing Wang, Min Wang, Binbin Xiang, Jingliang Qin, Ting Yao, Wanwu Li, Pan Wu, Qian Wang, Jianji Zhang, Yanli Xu, Miaomiao Liu, Yanling Wang, Guozhen Ma, Ruiying Liu, Xiaoya Li, Zimeng Huai, Yu Huang, Han Guo, Bin Yang, Lu Feng, Di Huang*, Kai Zhang*, Lei Wang*, Bin Liu*. Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation. Nature Microbiology. 2025. 10(3):749-764 (IF: 20.5)

3. Hao Sun, Xiaoya Li, Xinyuan Yang, Jingliang Qin, Yutao Liu, Yangyang Zheng, Qian Wang, Ruiying Liu, Hongmin Sun, Xintong Chen, Qiyue Zhang, Tianyuan Jia³, Xiaoxue Wu, Lu Feng, Lei Wang^* and Bin Liu^*. Low Leucine Levels in the Blood Enhance the Pathogenicity of Neonatal Meningitis-Causing Escherichia coli. Nature Communications. 2025. 16(1): 2466 (IF:14.7)

4. Bin Liu*#, Yutao Liu#, Bin Yang, Qian Wang, Xingmei Liu, Jingliang Qin, Ke Zhao, Fan Li, Xiaohui Feng, Linxing Li, Pan Wu, Miaomiao Liu, Siwei Zhu, Lu Feng, Lei Wang*. Escherichia coli O157:H7 senses microbiota-produced riboflavin to increase its virulence in the gut. PNAS. 2022. 119(48):e2212436119. (IF:9.5)

5. Linxing Li, Bin Yang, Jing Wang, Yi Wei, Binbin Xiang, Yutao Liu, Pan Wu, Wanwu Li, Yanling Wang, Xinyu Zhao, Jingliang Qin, Miaomiao Liu, Ruiying Liu, Guozhen Ma, Tian Fu, Min Wang*, Bin Liu*. CobB-mediated deacetylation of the chaperone CesA regulates Escherichia coli O157:H7 virulence. Gut Microbes. 2024.16(1):2331435. (IF:12.2)

6. Xingmei Liu, Yutao Liu, Xinyu Zhao, Xueping Li, Ting Yao, Ruiying Liu, Qian Wang, Qiushi Wang, Dan Li, Xintong Chen, Bin Liu*, Lu Feng*. Salmonella enterica serovar Typhimurium remodels mitochondrial dynamics of macrophages via the T3SS effector SipA to promote intracellular proliferation. Gut Microbes. 2024. 16(1):2316932. (IF:12.2)

7. Bin Liu#, Lingyan Jiang#, Yutao Liu#, Hongmin Sun, Jun Yan, Chenbo Kang, Bin Yang. Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization. Nature Communications. 2023.14(1):7227. (IF:14.7)

8. Tianyuan Jia, Pan Wu, Bin Liu, Miaomiao Liu, Huiqian Mu, Dan Liu, Min Huang, Linxing Li, Yi Wei, Lu Wang, Qian Yang, Yutao Liu, Bin Yang, Di Huang, Liang Yang, Bin Liu*. The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization. Science Signaling. 2023. 16(767):eabm0488. (IF:9.5)

9. Jialin Wu, Yutao Liu, Wendi Li, Fan Li, Ruiying Liu, Hao Sun, Jingliang Qin, Xiaohui Feng, Di Huang*, Bin Liu*. MlrA, a MerR family regulator in Vibrio cholerae, senses the anaerobic signal in the small intestine of the host to promote bacterial intestinal colonization. Gut Microbes. 2022.14(1):2143216. (IF:12.2)

10. Yutao Liu#, Bin Liu#, Tingting Xu#, Qian Wang, Wendi Li, Jialin Wu, Xiaoyu Zheng, Bin Liu, Ruiying Liu, Xingmei Liu, Xi Guo, Lu Feng, Lei Wang. A fructose/H+ symporter controlled by a LacI-type regulator promotes survival of pandemic Vibrio cholerae in seawater. Nature Communications. 2021.12(1):4649. (IF:14.7)

11. Yuhui Wang, Xiaohan Wang, Guozhen Ma, Lijie Xie, Dan Liu, Yanling Wang, Xinyu Zhao, Yingying Su, Andrei V. Perepelov, Peng Ding, Xiao Zhang, Bo Xu, Bin Liu*, Di Huang*. Sustainable production of a polysaccharide-based glycoprotein by simultaneous conversion of glucose and glycerol in engineered Escherichia coli. Green Chemistry. 2023. 25, 4818–4832(IF:9.3)

12. Yuhui Wang, Andrei V Perepelov, Sof'ya N Senchenkova, Gege Lu, Xiaohan Wang, Guozhen Ma, Qian Yang, Jian Yuan, Yanling Wang, Lijie Xie, Xiaolong Jiang, Jingliang Qin, Dan Liu, Miaomiao Liu, Di Huang*, Bin Liu*. Glycoengineering directs de novo biomanufacturing of UPEC O21 O-antigen polysaccharide based glycoprotein. International Journal of Biological Macromolecules. 2023.253(Pt 4):126993. (IF:8.2)

13. Yangyang Zheng, Hao Sun, Yanling Wang, Chen Jin, Xiaoya Li, Yu Pang, Qianwen Ge, Lei Wang, Bin Liu*. CsiR-Mediated Signal Transduction Pathway in Response to Low Iron Conditions Promotes Escherichia coli K1 Invasion and Penetration of the Blood-Brain Barrier. Journal of Infectious Diseases. 2024. 230(4):e807-e817 (IF:5.0)

14. Yuhui Wang, Haining Tan, Yanling Wang, Jing Liang Qin, Xinyu Zhao, Yuhan Di, Lijie Xie, Yujie Wang, Xiaojing Zhao, Ziyu Li, Guozhen Ma, Lingyan Jiang, Bin Liu*, Di Huang*. High-Level Biosynthesis of Chlorogenic Acid from Mixed Carbon Sources of Xylose and Glucose through a Rationally Refactored Pathway Network. Journal of Agricultural and Food Chemistry. 2024.72(7):3633-3643. (IF:5.7)

15. Tianyuan Jia, Bin Liu, Huiqian Mu, Chengqian Qian, Lu Wang, Linxing Li, Gege Lu, Wenxuan Zhu, Xi Guo, Bin Yang, Di Huang, Lu Feng, Bin Liu*. A novel small RNA promotes motility and virulence of enterohemorrhagic 

Escherichia coli O157:H7 in response to ammonium. mBio 2021. 12(2): e03605-20. (IF:7.8)

16. Bin Liu#, Chengqian Qian#, Pan Wu, Xiaodan Li, Yutao Liu, Huiqian Mu, Min Huang, Yang Zhang, Tianyuan Jia, Yuanyuan Wang, Lu Wang, Xiao Zhang, Di Huang, Bin Yang, Lu Feng, Lei Wang. Attachment of enterohemorrhagic Escherichia coli to host cells reduces O antigen chain length at the infection site that promotes infection. mBio 2021. 12(6): e0269221. (IF:7.8)

17. Min Wang, Bin Liu, Yanli Xu, Xi Guo, Tian Fu, Jiafei Liu, Bin Liu*, Lei Wang*.  Characterization of the O-antigen gene clusters and development of a molecular serotyping method for Vibrio fluvialis. International Journal of Food Microbiology. 2022. 370:109665. (IF:5.3)

18. Chengqian Qian, Min Huang, Yuhui Du, Jingjie Song, Huiqian Mu, Yi Wei, Si Zhang, Zhiqiu Yin, Chao Yuan, Bin Liu*, Bin Liu*. Chemotaxis and Shorter O-Antigen Chain Length Contribute to the Strong Desiccation Tolerance of a Food-Isolated Cronobacter sakazakii Strain. Front Microbiol. 2022. 4:12:779538. (IF:4.0)

19. Lu Wang, Pan Wu, Yingying Su, Yi Wei, Xi Guo, Lan Yang, Min Wang*, Bin Liu*. Detection of Genus and Three Important Species of Cronobacter Using Novel Genus- and Species-Specific Genes Identified by Large-Scale Comparative Genomic Analysis. Front Microbiol. 2022.13:885543. (IF:4.0)

20. Jian Yuan, Xiaolong Jiang, Huijing Zhang, Jing Bai, Jing Zhang, Yuhui Wang,  Gege Lu, Huimin Xu, Huanhuan Liu*, Bin Liu*, Di Huang*. Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3. Green Chemistry. 2021. 23:2668-2684. (IF:9.3)

21. Lu Wang, Wenxuan Zhu, Gege Lu, Pan Wu, Yi Wei, Yingying Su, Tianyuan Jia, Linxing Li, Xi Guo, Min Huang, Qian Yang, Di Huang*, Bin Liu*. In silico species identification and serotyping for Cronobacter isolates by use of whole-genome sequencing data. International Journal of Food Microbiology. 2021. 358:109405. (IF:5.3)

22. Bin Liu#, Axel Furevi#, Andrei V Perepelov#, Xi Guo#, Hengchun Cao, Quan Wang, Peter R Reeves, Yuriy A Knirel, Lei Wang, Göran Widmalm. Structure and genetics of Escherichia coli O antigens. FEMS Microbiology Reviews. 2020. 44(6):655-683. (IF:10.1)

23. Jiang L, Wang P, Li X, Lv R, Wang L, Yang B, Huang D, Feng L*, Liu B*.  PagR mediates the precise regulation of Salmonella pathogenicity island 2 gene expression in response to magnesium and phosphate signals in Salmonella Typhimurium. Cellular Microbiology. 2020.22(2):e13125. (IF:4.1)

24. Bin Liu, Junyue Wang, Lu Wang, Peng Ding, Pan Yang, Bin Yang. Transcriptional activator OvrA encoded in O island 19 modulates virulence gene expression in enterohemorrhagic Escherichia coli O157:H7. Journal of Infectious Diseases. 2020. 221(5):820-829. (IF:5.3)

25. Min Wang, Lu Wang, Pan Wu, Tingting Chen, Yiming Zhu, Yang Zhang, Yi Wei, Chengqian Qian, Yuhui Wang, Bin Liu*. Genomics and experimental analysis reveal a novel factor contributing to the virulence of Cronobacter sakazakii strains associated with neonate infection. Journal of Infectious Diseases. 2019. 220(2):306-315. (IF:5.3)

26. Liu Y#, Liu B#, Yang P, Wang T, Chang Z, Wang J, Wang Q, Li W, Wu J, Huang D, Jiang L, Yang B. LysR-type transcriptional regulator OvrB encoded in O island 9 drives enterohemorrhagic Escherichia coli O157:H7 virulence. Virulence. 2019. 10:783-792. (IF:5.4)

27. Dalong Hu#, Bin Liu#, Lu Feng, Peng Ding, Xi Guo, Min Wang, Boyang Cao, Peter R Reeves, Lei Wang. Origins of the current seventh cholera pandemic, PNAS. 2016. 113:E7730-E7739. (IF:9.5)

28. Hu D, Yin Z, Yuan C, Yang P, Qian C, Wei Y, Zhang S, Wang Y, Yuan J, Wang M, Reeves PR, Tu L, Chen M*, Huang D*, Liu B*. Changing molecular epidemiology of Vibrio cholerae outbreaks in Shanghai, China. mSystems 2019.  4(6):e00561-19. (IF:5.0)

29. Xiaojun Zhang, Jianbo Yuan, Yamin Sun, Shihao Li, Yi Gao, Yang Yu, Chengzhang Liu, Quanchao Wang, Xinjia Lv, Xiaoxi Zhang, Ka Yan Ma, Xiaobo Wang, Wenchao Lin, Long Wang, Xueli Zhu, Chengsong Zhang, Jiquan Zhang, Songjun Jin, Kuijie Yu, Jie Kong, Peng Xu, Jack Chen, Hongbin Zhang, Patrick Sorgeloos, Amir Sagi, Acacia Alcivar-Warren, Zhanjiang Liu, Lei Wang, Jue Ruan, Ka Hou Chu*, Bin Liu*, Fuhua Li*, Jianhai Xiang*. Penaeid shrimp genome provides insights into benthic adaptation and frequent molting. Nature Communications. 2019.10(1):356. (IF:14.7)

30. Yuan C, Yin Z, Wang J, Qian C, Wei Y, Zhang S, Jiang L*, Liu B*.  Comparative genomic analysis of Citrobacter and key genes essential for the pathogenicity of Citrobacter koseri. Front Microbiol. 2019.10:2774. (IF:4.0)

31. Liu H, Zhang J, Yuan J, Jiang X, Jiang L, Zhao G, Huang D*, Liu B*. Omics-based analyses revealed metabolic responses of Clostridium acetobutylicum to lignocellulose-derived inhibitors furfural, formic acid and phenol stress for butanol fermentation. Biotechnol Biofuels 2019.12:101. (IF:4.3)

32. Yu Pang, Xi Guo, Xiao Tian, Fenxia Liu, Lu Wang, Junli Wu, Si Zhang, Shujie Li, Bin Liu*. Developing a novel molecular serotyping system based on capsular polysaccharide synthesis gene clusters of Vibrio parahaemolyticus. International Journal of Food Microbiology. 2019. 309:108332. (IF:5.3)

33. Zhiqiu Yin; Chao Yuan; Yuhui Du; Pan Yang; Chengqian Qian; Yi Wei; Si Zhang; Di Huang*; Bin Liu*. Comparative genomic analysis of the Hafnia genus reveals an explicit evolutionary relationship between the species alvei and paralvei and provides insights into pathogenicity. BMC Genomics. 2019. 20: 768. (IF:4.0)

34. Min Wang; Hengchun Cao; Qian Wang; Tingting Xu; Xi Guo, Bin Liu*.The Roles of Two Type VI Secretion Systems in Cronobacter sakazakii ATCC 12868. Frontiers in Microbiology. 2018. 9:2499. (IF:4.0)

35. Huiying Li; Xiaomin Li; Runxia Lv; Xiaolong Jiang; Hengchun Cao; Yuhui Du; Lingyan Jiang*; Bin Liu*. Global regulatory function of the low oxygen-induced transcriptional regulator LoiA in Salmonella Typhimurium revealed by RNA sequencing. Biochemical and Biophysical Research Communications. 2018.503(3):2022-2027 (IF:2.6)

36. Hengchun Cao; Min Wang; Qian Wang; Tingting Xu; Yuhui Du; Huiying Li; Chengqian Qian; Zhiqiu Yin; Lu Wang; Yi Wei; Pan Wu; Xi Guo; Bin Yang*; Bin Liu*. Identifying genetic diversity of O antigens in Aeromonas hydrophila for molecular serotype detection. PLoS One. 2018.13(9): e0203445 (IF:2.8)

37. Xu T, Cao H, Zhu W, Wang M, Du Y, Yin Z, Chen M, Liu Y, Yang B, Liu B*. RNA-seq-based monitoring of gene expression changes of viable but non-culturable state of Vibrio cholerae induced by cold sea water. Environ Microbiol Rep. 2018. 10(5):594-604. (IF:4.0)

38. Xi Guo#; Bin Liu#; Min Chen#; Yao Wang; Hongyou Chen; Lu Wang; Lihong Tu; Xi Zhang; Lu Feng. Genetic and serological identification of three Vibrio parahaemolyticus strains as candidates for novel provisional O serotypes. International Journal of Food Microbiology. 2017. 245: 53~58 (IF:5.3)

39. Bin Liu#; Gustavo Eydallin#; Ram P. Maharjan; Lu Feng; Lei Wang; Thomas Ferenci. Natural Escherichia coli isolates rapidly acquire genetic changes upon laboratory domestication. Microbiology-SGM. 2017.163(1):22-30 (IF:1.9)

40. Di Huang, Kexin Yang, Jia Liu, Yingying Xu, Yuanyuan Wang, Ru Wang, Bin Liu*, Lu Feng*.Metabolic engineering of Escherichia coli for the production of 2’-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. Metabolic Engineering. 2017. 41: 23-38. (IF:8.8)

41. Ram P. Maharjan#; Bin Liu#; Lu Feng; Thomas Ferenci; Lei Wang. Simple phenotypic sweeps hide complex genetic changes in populations. Genome Biology and Evolution. 2015. 7(2): 531~544 (IF:3.7)

42. Bin Liu, Yuriy A Knirel, Lu Feng, Andrei V Perepelov, Sof'ya N Senchenkova, Peter R Reeves, Lei Wang. Structural diversity in Salmonella O antigens and its genetic basis. FEMS Microbiology Reviews. 2014. 38(1):56-89. (IF:10.1)

43. Bin Liu, Hu B, Zhou Z, Guo D, Guo X, Ding P, Feng L, Wang L. A novel nonhomologous recombination-mediated mechanism for Escherichia coli unilateral flagellar phase variation. Nucleic Acids Res. 2012. 40(10):4530-4538. (IF:16.6)

44. Bin Liu, Chen M, Perepelov AV, Liu J, Ovchinnikova OG, Zhou D, Feng L, Rozalski A, Knirel YA, Wang L. Genetic analysis of the O-antigen of Providencia alcalifaciens O30 and biochemical characterization of a formyltransferase involved in the synthesis of a Qui4N derivative. Glycobiology 2012. 22(9):1236-1244. (IF:3.4)

45. Changchang Xu#; Bin Liu#; Bo Hu; Yanfang Han; Lu Feng; John Allingham; Walter A. Szarek; Lei Wang; Inka Brockhausen. Biochemical characterization of a new enzyme from Shigella boydii type 14 that catalyzes the second step in O-antigen repeating unit synthesis: UDP-Gal:GlcNAc-pyrophosphate-lipid 1,4-galactosyltransferase WfeD. Journal of Bacteriology. 2011. 193(2): 449~459 (IF:3.2)

46. Liu B#, Perepelov AV#, Svensson MV#, Shevelev SD, Guo D, Senchenkova SN, Shashkov AS, Weintraub A, Feng L, Widmalm G, Knirel YA, Wang L. 2010. Genetic and structural relationships of Salmonella O55 and Escherichia coli O103 O-antigens and identification of a 3-hydroxybutanoyltransferase gene involved in the synthesis of a Fuc3N derivative. Glycobiology 20(6):679-688. (IF:3.4)

47. Bin Liu, Yuriy A Knirel, Lu Feng, Andrei V Perepelov, Sof'ya N Senchenkova, Quan Wang, Peter R Reeves, Lei Wang. Structure and genetics of Shigella O antigens. FEMS Microbiology Reviews. 2008.32(4): 627-653. (IF:10.1)