周道国

发布者:禇佳强发布时间:2017-02-28浏览次数:298

周道国

学历: 博士
职称: 讲席教授、国家千人计划入选者
专业方向: 病原微生物学、细胞微生物学、病原微生物与宿主的相互作用、微生物基因组学
招生专业: 微生物学、生物化学与分子生物学
人员简介:

    周道国,1962出生,美国普渡大学生命科学系教授,现任南开大学讲席教授;1983毕业于武汉大学微生物学专业,获学士学位,1995年获美国爱荷华大学博士学位,曾在美国纽约州立大学石溪分校、耶鲁大学完成博士后研究,美国加州大学旧金山分校做访问学者;2000年起在美国普渡大学先后任助理教授、副教授、教授。周教授长期致力于致病性细菌的分子遗传学及致病性机理研究,研究领域涉及细胞微生物学、鼠伤寒沙门氏菌及III型分泌系统效应蛋白在细菌与宿主相互作用过程中的功能。累计在国际权威杂志发表SCI收录论文40余篇,其中以第一作者或通讯作者身份发表论文30篇,包括《Science》发表1篇、《PNAS》发表2篇、《Nature Structural & Molecular Biology》发表1篇、《Molecular Microbiology》发表5篇等;参与编写著作1部。

    2001年至今主持国家自然科学基金委海外、港澳青年学者合作研究科学基金项目1项,国家自然科学基金委和美国国立卫生研究院中美生物医学合作研究基金项目1项,美国国立卫生研究院(NIH)项目5项,美国心脏协会(AHA)项目1项。

    Email:zhoudaoguo@nankai.edu.cn  电话:022-66229900


发表论文:

1.Piscatelli, H. L., M. Li, and D. Zhou. 2015. Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry. Cell. Microbiol.

2.Zhao, E. Y., H. X. Bao, L. Tang, Q. H. Zou, W. Q. Liu, D. L. Zhu, J. Chin, Y. Y. Dong, Y. G. Li, F. L. Cao, C. Poppe, K. E. Sanderson, R. N. Johnston, D. Zhou, G. R. Liu, and S. L. Liu. 2013. Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains. Mol Genet Genomics 288:549-57.

3.Perrett, C. A., and D. Zhou. 2013. Salmonella type III effector SopB modulates host cell exocytosis. Emerg Microbes Infect 2:e32.

4.Myeni, S. K., L. Wang, and D. Zhou. 2013. SipB-SipC complex is essential for translocon formation. PLoS ONE 8:e60499.

5.Li, D., X. Wang, L. Wang, and D. Zhou. 2013. The actin-polymerizing activity of SipA is not essential for Salmonella enterica serovar Typhimurium-induced mucosal inflammation. Infect. Immun. 81:1541-9.

6.Piscatelli, H., S. A. Kotkar, M. E. McBee, S. Muthupalani, D. B. Schauer, R. E. Mandrell, J. M. Leong, and D. Zhou. 2011. The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS ONE 6:e19331.

7.Perrett, C. A., and D. Zhou. 2011. Type three secretion system effector translocation: one step or two? Front. Microbiol. 2:50.

8.Perrett, C. A., D. Y. Lin, and D. Zhou. 2011. Interactions of bacterial proteins with host eukaryotic ubiquitin pathways. Front. Microbiol. 2:143.

9.Lin, D. Y., J. Diao, D. Zhou, and J. Chen. 2011. Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7. J. Biol. Chem. 286:441-9.

10.Wang, X., D. Li, D. Qu, and D. Zhou. 2010. Involvement of TIP60 acetyltransferase in intracellular Salmonella replication. BMC Microbiol 10:228.

11.Srikanth, C. V., D. M. Wall, A. Maldonado-Contreras, H. N. Shi, D. Zhou, Z. Demma, K. L. Mumy, and B. A. McCormick. 2010. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science 330:390-3.

12.Myeni, S. K., and D. Zhou. 2010. The C terminus of SipC binds and bundles F-actin to promote Salmonella invasion. J. Biol. Chem. 285:13357-63.

13.Wang, X., and D. Zhou. 2009. Salmonella Invasion. J Microbes Infect 4:112-128.

14.Diao, J., Y. Zhang, J. M. Huibregtse, D. Zhou, and J. Chen. 2008. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat. Struct. Mol. Biol. 15:65-70.

15.Dai, S., Y. Zhang, T. Weimbs, M. B. Yaffe, and D. Zhou. 2007. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic 8:1365-74.

16.Chang, J., S. K. Myeni, T. L. Lin, C. C. Wu, C. J. Staiger, and D. Zhou. 2007. SipC multimerization promotes actin nucleation and contributes to Salmonella-induced inflammation. Mol. Microbiol. 66:1548-56.

17.Zuo, X., J. Zhang, Y. Zhang, S. C. Hsu, D. Zhou, and W. Guo. 2006. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat. Cell Biol. 8:1383-8.

18.Zhang, Y., W. M. Higashide, B. A. McCormick, J. Chen, and D. Zhou. 2006. The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol. Microbiol. 62:786-93.

19.Hu, H., Q. Sa, T. M. Koehler, A. I. Aronson, and D. Zhou. 2006. Inactivation of Bacillus anthracis spores in murine primary macrophages. Cell. Microbiol. 8:1634-1642.

20.Higashide, W., and D. Zhou. 2006. The first 45 amino acids of SopA are necessary for InvB binding and SPI-1 secretion. J. Bacteriol. 188:2411-20.

21.Zhang, Y., W. Higashide, S. Dai, D. M. Sherman, and D. Zhou. 2005. Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. J. Biol. Chem. 280:38682-8.

22.Chang, J., J. Chen, and D. Zhou. 2005. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Mol. Microbiol. 55:1379 - 89.

23.Zhou, D. 2004. Bacterial invasion into non-phagocytic cells, p. 247-273. In C. A. Nickerson and M. J. Schurr (ed.), Molecular Paradigms of Infectious Disease. Springer Ecience+Business Media, LLC.

24.Dai, S., and D. Zhou. 2004. Secretion and function of Salmonella SPI-2 effector SseF require its chaperone, SscB. J. Bacteriol. 186:5078-86.

25.Dai, S., P. D. Sarmiere, O. Wiggan, J. R. Bamburg, and D. Zhou. 2004. Efficient Salmonella entry requires activity cycles of host ADF and cofilin. Cell. Microbiol. 6:459-71.

26.Higashide, W., S. Dai, V. P. Hombs, and D. Zhou. 2002. Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells. Cell. Microbiol. 4:357-65.

27.Galkin, V. E., A. Orlova, M. S. VanLoock, D. Zhou, J. E. Galán, and E. H. Egelman. 2002. The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin. Nat. Struct. Biol. 9:518-21.

28.Zhou, D., and J. E. Galán. 2001. Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect. 3:1293-8.

29.Zhou, D., L. M. Chen, L. Hernandez, S. B. Shears, and J. E. Galán. 2001. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol. Microbiol. 39:248-59.

30.Zhou, D. 2001. Collective efforts to modulate the host actin cytoskeleton by Salmonella type III-secreted effector proteins. Trends Microbiol. 9:567-9; discussion 569-70.

31.Mitra, K., D. Zhou, and J. E. Galán. 2000. Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica. FEBS Lett. 482:81-84.

32.Galan, J. E., and D. Zhou. 2000. Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc. Natl. Acad. Sci. U. S. A. 97:8754-61.

33.Zhou, D., M. S. Mooseker, and J. E. Galán. 1999. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Proc. Natl. Acad. Sci. U. S. A. 96:10176-81.

34.Zhou, D., M. S. Mooseker, and J. E. Galán. 1999. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science 283:2092-5.

35.Zhou, D., W. D. Hardt, and J. E. Galan. 1999. Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island. Infect. Immun. 67:1974-81.

36.Estabrook, M. M., D. Zhou, and M. A. Apicella. 1998. Nonopsonic phagocytosis of group C Neisseria meningitidis by human neutrophils. Infect. Immun. 66:1028-36.

37.Zhou, D., and M. A. Apicella. 1996. Plasmids with erythromycin resistance and catechol 2,3-dioxygenase- or beta-galactosidase-encoding gene cassettes for use in Neisseria spp. Gene 171:133-4.

38.Apicella, M. A., M. Ketterer, F. K. Lee, D. Zhou, P. A. Rice, and M. S. Blake. 1996. The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae. J. Infect. Dis. 173:636-46.

39.Lee, F. K., D. S. Stephens, B. W. Gibson, J. J. Engstrom, D. Zhou, and M. A. Apicella. 1995. Microheterogeneity of Neisseria lipooligosaccharide: analysis of a UDP-glucose 4-epimerase mutant of Neisseria meningitidis NMB. Infect. Immun. 63:2508-15.

40.Zhou, D., D. S. Stephens, B. W. Gibson, J. J. Engstrom, C. F. McAllister, F. K. Lee, and M. A. Apicella. 1994. Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the phosphoglucomutase gene. J. Biol. Chem. 269:11162-9.

41.Zhou, D., N. G. Lee, and M. A. Apicella. 1994. Lipooligosaccharide biosynthesis in Neisseria gonorrhoeae: cloning, identification and characterization of the alpha 1,5 heptosyltransferase I gene (rfaC). Mol. Microbiol. 14:609-18.

42.Stephens, D. S., C. F. McAllister, D. Zhou, F. K. Lee, and M. A. Apicella. 1994. Tn916-generated, lipooligosaccharide mutants of Neisseria meningitidis and Neisseria gonorrhoeae. Infect. Immun. 62:2947-52.

43.Kim, J. J., D. Zhou, R. E. Mandrell, and J. M. Griffiss. 1992. Effect of exogenous sialylation of the lipooligosaccharide of Neisseria gonorrhoeae on opsonophagocytosis. Infect. Immun. 60:4439-42


著作:

Zhou, D. 2003. Bacterial Invasion into Non-Phagocytic Cells. In Molecular Paradigms of Infectious Disease. In Press. Nickerson, C. and Schurr, M. (eds): Kluwer Academic/Plenum Publishers.